Advantages of the Twin-Screw Extruder in Hot-Melt Extrusion
The proprietary
hot-melt extrusion
process is carried out with the use of an extruder. An extruder is a barrel
with a platform supporting either one or two rotating screws that are used to
push substances down the barrel. Extruders are of two types, namely, the single
screw extruders and the twin-screw extruders.
Continue reading this blog to learn
more about the twin-screw extruders and their advantages in hot-melt
extrusion.
At AbbVie, we handle your product as
our own. The nature of your biological drug notwithstanding, you can count on
us when it comes to hme
services. We will
provide reliable and safe products that patients are ready to use.
Twin-Screw Extruders
Twin-screw extruders are more
advanced devices that contain twin-screw systems, having counter-rotating or
co-rotating screws. These extruders are used to melt polymers and mix them with
other substances such as pigments and APIs. They can also be used to remove
volatile materials.
This type of screw usually consists
of length-to-diameter ratio. And this is generally around twenty to forty
ration one. The extruders generally used in pre-commercial plants are between
eighteen to thirty millimeters in diameter. While those used for its production
have a much higher diameter that typically exceeds fifty millimeters.
1. It Has Lower
Tendency to Overheat
Increasing the speed of the screws in
the single-screw extruder produces heat. And this can degrade drugs that are
delicate to an elevated temperature. Heat is controlled with twin-screw
extruders. This is achieved by external sources and produced independently of
screw speed. The tendency to overheat is much lower, which represents an
essential advantage for heat-sensitive drugs and for decreasing residence time.
2. Increased Versatility
Twin-screw extruder enables varying
conditions and different configurations in the different extruder zones.
Different varieties of twin-screw extruders are, thus, available with various
operating mechanisms that can be used for diverse applications.
3. Increased
Flexibility
Process consideration can
continuously and easily be controlled. This depends on the mixing function and
extrusion. The die plates are also quickly changed if a dissimilar
extrudate diameter is preferred, which means a wide range of formulations can
be processed using a single device.
4. It is
Self-Cleaning
In this type of extruder with
intermeshing co-rotating screws, one of the screws’ flights wipes the base of
the parallel screw. And this ensures the total emptying of the device. It also
reduces the quantity of wasted product at the end of each batch.
5. Decreased
Residence Time
The durability of time a substance stays in the extruder is reduced,
basically because of the relatively quick-melting time when compared to the
length of time required in a single-screw extruder. Extrusion process typically
lasts between 5-10 minutes.
6. Improved Mixing
Better mixing is achieved with
twin-screw extruders because of the intermeshing co-rotating screws. Either
dispersive mixing or distributive mixing can be achieved. Distributive mixing
enables limited degradation and the even blending of substances, which is
advantageous for processing APIs that are sensitive to shearing or heat.

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