Advantages and Disadvantages of Proprietary Hot Melt Extrusion

Hot Melt Extrusion services have advanced as an exceptional processing technology in producing molecular dispersions API into various lipid and polymer matrices. And this has led to targeted, extended, modified, and time-regulated drug delivery. Today, Hot Melt Extrusion allows us to use compounds to mask the bitter taste of active drugs.

Since the industrial application of the extrusion process in the 1930s, propriety HME has gotten massive attention from the academia and pharmaceutical industry for a variety of applications for various applications for pharmaceutical dosage forms like films, capsules, tablets, and implants for drug delivery through transmucosal, transdermal, and oral routes.

As a result, Hot Melt Extrusion services are a suitable alternative to other commonly used processes, such as spray drying and roll spinning at AbbVie Contract Manufacturing. In addition, we offer the best proprietary HME services in both Europe and the US. We are a leading company with over three decades of Hot Melt Extrusion development experience and the most commercial products launched using this outstanding technology.

Advantages

Proprietary Hot Melt Extrusion has several benefits over presently used pharmaceutical processing methods, which include:

1. Automation

Hot Melt Extrusion allows for simple and quick processing and production of dosage forms, which transforms into greater yields and a shorter time to market.

2. Increases Solubility

Proprietary Hot Melt Extrusion increases solubility because binder components of Hot Melt Extrusion dissolve quickly in water to yield the free soluble active pharmaceutical ingredients inside the drug delivery matrix.

3. Excellent Content Uniformity

Proprietary Hot Melt Extrusion has a higher variability than other conventional uses, such as spray drying. This is the main advantage since it allows for a more uniform content of the API because of the uniformity in the consistency of pressure distribution and the flow rate of material during extrusion.

4. There is no Requirement for Compressibility

In Proprietary Hot Melt Extrusion, there is no need for compressibility because of its low operating pressure. And this does not require a high vacuum.

Disadvantages of Proprietary Hot Melt Extrusion

Like everything that has merits, Proprietary Hot Melt Extrusion also has downsides, which we have highlighted below:

1. High Heat Sensitivity

The requirement of excipients that aren’t ideal for high heat sensitivity molecules such as proteins and microbial species are the significant limitations of Proprietary Hot Melt Extrusion.

2. Using a Restricted Number of Polymers

Proprietary Hot Melt Extrusion cannot endure many additives like other processing methods, such as spray drying. So, Proprietary Hot Melt Extrusion is limited to a few polymers.

In summary, Proprietary Hot Melt Extrusion has proven to be a suitable method of manufacturing various drug delivery systems. It thus has been found to be invaluable in the pharmaceutical industry, thereby enlarging the scope to include a range of active pharmaceutical ingredients ad polymers that can be processed with or without plasticizers.

It has also been noted that Proprietary Hot Melt Extrusion is a solvent-free, strong, economy, and quick-favored manufacturing process for the manufacturing of a large variety of pharmaceutical dosage forms.